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Zina Ben Miled, Purdue University (Indianapolis) Department of Electrical Engineering

Fortes, Purdue University School of Electrical and Computer Engineering Figueiredo, Purdue University School of Electrical and Computer Engineering Functional impairment in Chagas disease is detectable in the early stages of cardiac involvement, even in the absence of systolic dysfunction and signs of heart failure.Impact of Computing-in-Memo on the Performance of Processor-and-Menlory Hierarchies Exercise capacity in Chagas disease patients without apparent cardiac disease is similar to that in healthy controls. VO2peak was also significantly lower (mean difference, -9.30ml/kg/min 95% CI, -11.34 to -7.25ml/kg/min) in dilated CHD patients (n=131) than in healthy controls (n=53 p<0.001, I2=0%). Chagas disease patients without apparent cardiac disease (n=208) had VO2peak values similar to those of healthy controls (n=105 p=0.38, I2=52%). Seven cross-sectional studies were included. We included studies that compared the VO2peak between healthy and Chagas disease patients, stratified according to 3 clinical forms. A systematic review and meta-analysis (PROSPERO database CRD42017058353) was conducted following a search of the MEDLINE, Web of Science, CINAHL, and LILACS databases from September to December 2017 for articles published in English, Spanish, or Portuguese, with no date restrictions. The present study compared functional capacity between healthy controls and patients with different clinical forms of Chagas disease. However, the disease stage in which functional impairment is detectable remains uncertain. BRĪbstract Reduced peak oxygen uptake (VO2peak) is a common clinical finding in progressive Chagas disease. Curso de Pós-Graduação em Infectologia e Medicina Tropical. Rocha, Manoel Otávio da Costa Universidade Federal de Minas Gerais.Faculdade de Ciências Biológicas e da Saúde. Figueiredo, Pedro Henrique Scheidt Universidade Federal dos Vales do Jequitinhonha e Mucuri.